Ancient Chinese remedy targets kidney disease at molecular level
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Researchers in China decoded how Danggui Buxue Decoction, an 800-year-old herbal formula, combats chronic glomerulonephritis, a kidney disease. The team chemically analyzed the formula, which combines Angelicae Sinensis Radix and Astragali Radix in a 1:5 ratio, identifying 104 compounds.
They then used computer modeling to predict how these compounds interact with the body, focusing on 166 overlapping targets related to the disease. Experiments using rat cells and live rats confirmed the predictions.
The formula reduced inflammation and restored programmed cell death, apoptosis, in kidney tissues damaged by the disease. Specifically, the formula impacted the TLR4/NF-κB signaling pathway, a key regulator of inflammation, and restored the balance between pro- and anti-apoptotic proteins. The researchers prepared drug-containing serum by administering the formula to rats, then used that serum in lab experiments. Rats treated with the herbal formula for 30 days showed improvements in urine protein levels, kidney function, and overall health.
This detailed analysis could provide a new understanding of traditional Chinese medicine and a possible complementary approach to current treatments for chronic glomerulonephritis, which include drugs with limitations and side effects.
